首頁 產品中心
  • GDC-0068
  • GDC0068,GDC 0068,GDC-0068,RG7440,RG-7440;,RG 7440
  • 貨號: abs810633
    CAS號: 1001264-89-6
    分子式: C24H32ClN5O2
    分子量: 458
    產品說明書
    分享:
    貨號-規格 貨期 價格 數量
    abs810633-5mg 現貨 ¥1386.00
    - +
    abs810633-10mg 現貨 ¥2079.00
    - +
    abs810633-50mg 現貨 ¥5544.00
    - +
    abs810633-100mg 現貨 ¥8085.00
    - +
    大包裝詢價
    產品描述
    描述

    GDC-0068 is a highly selective pan-Akt inhibitor targeting Akt1, Akt2 and Akt3 with IC50 of 5 nM, 18 nM and 8 nM, respectively.

    純度
    >98%
    儲存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -80℃ for six months.
    基本信息
    別名
    GDC0068,GDC 0068,GDC-0068,RG7440,RG-7440;,RG 7440
    外觀
    Powder
    可溶性/溶解性
    DMSO 92 mg/mL (200.87 mM)

    Ethanol 92 mg/mL (200.87 mM)

    Water <1 mg/mLbr>


    生物活性
    靶點
    Akt1 ,Akt3 ,Akt2
    In vitro(體外研究)
    Testing against a broad panel of 230 kinases, GDC-0068 only inhibits 3 kinases by >70% at 1 μM concentration (PRKG1α, PRKG1β, and p70S6K, with IC50 of 98 nM, 69 nM, and 860 nM, respectively). GDC-0068 displays >100-fold selectivity for Akt over PKA with IC50 of 3.1 μM. In LNCaP, PC3 and BT474M1 cells, GDC-0068 treatment inhibits the phosphorylation of the Akt substrate, PRAS40 with IC50 of 157 nM, 197 nM, and 208 nM, respectively. Furthermore, GDC-0068 selectively inhibits cell cycle progression and viability of cancer cell lines driven by Akt signaling, including those with defects in the tumor suppressor PTEN, oncogenic mutations in PIK3CA, and amplification of HER2, with strongest effects in HER2+ and Luminal subtypes.
    In vivo(體內研究)
    Oral administration of GDC-0068 in PC3 prostate tumor xenografts model induces down-regulation of p-PRAS40. In BT474-Tr xenografts, GDC-0068 treatment reduces pS6 and peIF4G levels, re-localizes FOXO3a to nucleus, and induces feedback upregulation of HER3 and pERK. Administration of GDC-0068 exhibits potent antitumor efficacy in multiple xenograft tumor models, including the PTEN-deficient prostate cancer models LNCaP and PC3, the PIK3CA H1047R mutant breast cancer model KPL-4, and MCF7-neo/HER2 tumor model.
    溫馨提示:本產品僅作科研實驗使用,不支持臨床等研究
        提示: 尊敬的客戶您好,如果您對我們的產品有什么疑問或想要了解的,可以點擊“我要提問”按鈕填寫您的疑問。
        提交不成功?請聯系[email protected]。
        我要提問

    促銷資訊 更多

      訂購信息
      您可以從我們的授權經銷商處購買absin產品或獲得技術支持。若要查看您所在地區的經銷商,請從以下的下拉列表中選擇。
      GO
      • 0
      打工不赚钱 上海11选5任三遗漏一定牛 1990至2017上证走势图 股票配资平台114 陕陕西11选5走式 体彩排三走势图带连线 时时彩软件免费试用版 北京快中彩开奖公告 江苏快3和值兑奖表 股票融资通俗的讲是什么意思 快乐十分app官方下载