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  • 霍亂毒素B亞單位
  • 霍亂毒素B亞基、CHOLERA TOXIN B SUBUNIT、CTB、 Cholera Toxin B subunit、CTxB、Choleragenoid
  • 貨號: abs80001
    CAS號: 131096-89-4
    分子量: 11kd
    產品說明書
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    貨號-規格 貨期 價格 數量
    abs80001-1mg 現貨 ¥2200.00
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    大包裝詢價
    產品描述
    描述

    Cholera toxin (CTB,霍亂毒素B亞基)belongs to the AB5 –subunit family oftoxins.The native hexameric protein has a molecular mass of ~85 kDa and contains two subunits. It consists of a single A subunit (~27.2 kDa), responsible for the ADP-ribosylation activity, and five B subunits(~11.6 kDa each), which are arranged as a pentameric ring with an apparent 5-fold symmetry and are associated with the cell surface receptor binding and subsequent internalization (transmembrane transport)of the enzymatic component.

    純度
    ≥95%
    儲存/保存方法
    2–8 °C, The product, as supplied, is stable 2 years when stored properly. Solutions
    are stable for at least 3 months when stored at 2–8 °C. DO NOT FREEZE.
    技術指標

    Format:Recombinant Source:E.coli Sodium azide:Not add.

    產品用途
    Cholera toxin and its purified A subunit are frequently used for the study of signal transduction mechanisms.In addition,cholera toxin acts as an adjuvant through the stimulation of B lymphocytes. The cholera toxin B subunit alone is used for track tracing in neurological research, taking advantage of GM1 ganglioside binding and retrograde transport.Tissue culture cells treated with cholera toxin are not killed and tissues of animals do not become necrotic.
    注意事項
    The B subunit is non-toxic to cells and possesses no intrinsic adenylate cyclase activity. The cholera toxin B subunit (CTB) attaches to cells by binding to ganglioside GM1.8 CTB has been shown to be a good label for microglial cells (due to the enrichment of ganglioside GM1 on their cell surface), but not for oligodendrocytes or astrocytes. The B subunit has been reported to be an excellent tracer for the study of axonal transport using immunohistochemical methods. Recently it has been widely used as a marker of membrane lipid rafts, which are membrane microdomains enriched with cholestrol and sphingolipids. These lipid rafts have an important role in cell signaling and protein trafficking.
    基本信息
    別名
    霍亂毒素B亞基、CHOLERA TOXIN B SUBUNIT、CTB、 Cholera Toxin B subunit、CTxB、Choleragenoid
    外觀
    powder
    可溶性/溶解性
    H2O: soluble 1mg/mL
    參考文獻
    參考文獻
    1. Nedelkoska, L., and Benjamins, J.A., Binding of cholera toxin B subunit: a surface marker for murine microglia but not oligodendrocytes or astrocytes. J. Neurosci. Res., 53, 605-612 (1998).
    2. Janes, P.W., et al., Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor. J. Cell Biol., 147, 447-461 (1999).
    溫馨提示:本產品僅作科研實驗使用,不支持臨床等研究
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