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  • Chlorpromazine hydrochloride
  • 鹽酸氯丙嗪;Chlorpromazine HCl
  • 貨號: abs817925
    CAS號: 69-09-0
    分子式: C17H20Cl2N2S
    分子量: 355.33
    產品說明書
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    貨號-規格 貨期 價格 數量
    abs817925-50mg 現貨 ¥210.00
    - +
    abs817925-100mg 1-2周 ¥336.00
    - +
    abs817925-500mg 1-2周 ¥473.00
    - +
    abs817925-1g 1-2周 ¥609.00
    - +
    ! 該貨號為 abs47029972 的新貨號。
    大包裝詢價
    產品描述
    描述

    Chlorpromazine Hydrochloride 是一種有效的 dopamine D2 受體,5-HT2A 受體,potassium channel,sodium channel 的拮抗劑,抑制 D2 受體和 serotonin 5-HT2A 受體的活性,Ki 值分別為 363 nM 和 8.3 nM。

    純度
    ≥98%
    儲存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months
    基本信息
    別名
    鹽酸氯丙嗪;Chlorpromazine HCl
    外觀
    白色粉末
    可溶性/溶解性
    DMSO : 50 mg/mL

    Water : 50 mg/mL

    Ethanol : 50 mg/mL
    生物活性
    靶點
    Dopamine receptor ,Potassium channel
    In vitro(體外研究)
    Chlorpromazine affects miniature IPSCs (mIPSCs) by decreasing the binding (kon) and by increasing the unbinding (koff) rates of GABAARs. Chlorpromazine modulates activated TRPA1 currents in a voltage-dependent way, leading to a block at positive potentials and an increased open probability at negative potentials.
    In vivo(體內研究)
    Chlorpromazine independently down-regulates the production of various T cell-derived lymphokines (IL-2, IFN-gamma, IL-4, TNF, and GM-CSF) and up-regulates the secretion of IL-10 in an in vivo model of acute superantigen-driven immune activation. Chlorpromazine -mediated amplification of the SEB-driven Chlorpromazine secretion is accompanied by an enhanced IL-10 mRNA accumulation. Chlorpromazine protects mice, normal or adrenalectomized, and guinea pigs against lethality of LPS, and inhibits TNF serum levels. Chlorpromazine protects against LPS lethality when administered 30 minutes (min) before, simultaneously, or up to 10 min after LPS and is ineffective when given 30 min after LPS, paralleling the inhibitory effect on TNF production. Chlorpromazine significantly inhibits LPS lethality and hepatotoxicity in mice sensitized to LPS toxicity by actinomycin D, whereas under these conditions DEX is inactive. Chlorpromazine protects brain tissue from hypoxia-induced irreversible loss of synaptic transmission in rats. Chlorpromazine also significantly delays the occurrence of the hypoxia-induced spreading depression (SD) in rats.
    參考文獻
    參考文獻
    [1] Mozrzymas JW, et al. J Neurosci, 1999, 19(7), 2474-2488.
    [2] Palacios, M., et al. 1993. Biochem. Biophys. Res. Commun. 196: 280-286.
    [3] Maor, I., et al. 1995. Arterioscler. Thromb. Vasc. Biol. 15: 1378-1387.
    [4] Netea, M.G., et al. 1995. J. Infect. Dis. 171: 393-399.
    [5] Lee, M.S., et al. 2007. Cancer Res. 67: 11359-11367.
    溫馨提示:本產品僅作科研實驗使用,不支持臨床等研究
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